Protein name:
Major vault protein (MVP) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs). Interacts with TEP1. Interacts with PTEN and activated MAPK1. The phosphorylated protein interacts with the SH2 domains of PTPN11 and SRC. Interacts with APEX1 (By similarity). May interact with ZNF540.
Function:
Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MATEEAIIRI | PPYHYIHVLD | QNSNVSRVEV | GPKTYIRQDN | ERVLFAPVRM |
100:
VTVPPRHYCI | VANPVSRDTQ | SSVLFDITGQ | VRLRHADQEI | RLAQDPFPLY |
150:
PGEVLEKDIT | PLQVVLPNTA | LHLKALLDFE | DKNGDKVMAG | DEWLFEGPGT |
200:
YIPQKEVEVV | EIIQATVIKQ | NQALRLRARK | ECFDREGKGR | VTGEEWLVRS |
250:
VGAYLPAVFE | EVLDLVDAVI | LTEKTALHLR | ALQNFRDLRG | VLHRTGEEWL |
300:
VTVQDTEAHV | PDVYEEVLGV | VPITTLGPRH | YCVILDPMGP | DGKNQLGQKR |
350:
VVKGEKSFFL | QPGERLERGI | QDVYVLSEQQ | GLLLKALQPL | EEGESEEKVS |
400:
HQAGDCWLIR | GPLEYVPSAK | VEVVEERQAI | PLDQNEGIYV | QDVKTGKVRA |
450:
VIGSTYMLTQ | DEVLWEKELP | SGVEELLNLG | HDPLADRGQK | GTAKPLQPSA |
500:
PRNKTRVVSY | RVPHNAAVQV | YDYRAKRARV | VFGPELVTLD | PEEQFTVLSL |
550:
SAGRPKRPHA | RRALCLLLGP | DFFTDVITIE | TADHARLQLQ | LAYNWHFELK |
600:
NRNDPAEAAK | LFSVPDFVGD | ACKAIASRVR | GAVASVTFDD | FHKNSARIIR |
650:
MAVFGFEMSE | DTGPDGTLLP | KARDQAVFPQ | NGLVVSSVDV | QSVEPVDQRT |
700:
RDALQRSVQL | AIEITTNSQE | AAAKHEAQRL | EQEARGRLER | QKILDQSEAE |
750:
KARKELLELE | AMSMAVESTG | NAKAEAESRA | EAARIEGEGS | VLQAKLKAQA |
800:
LAIETEAELE | RVKKVREMEL | IYARAQLELE | VSKAQQLANV | EAKKFKEMTE |
850:
ALGPGTIRDL | AVAGPEMQVK | LLQSLGLKST | LITDGSSPIN | LFSTAFGLLG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
Chicken
Polyclonal Antibody for Rat MVP
Polyclonal Antibody for Rat MVP
Polyclonal Antibody for Rat MVP
Polyclonal Antibody for Rat MVP
Polyclonal Antibody for Rat MVP
Monoclonal Antibody for Rat MVP
Monoclonal Antibody for Rat MVP
Monoclonal Antibody for Rat MVP
Monoclonal Antibody for Rat MVP
Monoclonal Antibody for Rat MVP
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO C-TERMINUS
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION WITH TEP1
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (9.0 ANGSTROMS);SUBUNIT
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS);SUBUNIT;MVP REPEATS